Research Edition is a powerful web application that integrates and unifies high-throughput cancer profiling data across a large volume of cancer types, subtypes, and experiments so that target expression can be assessed in seconds. A premium upgrade adds functionality and allows users to search the Oncomine database for enrichment of user-defined gene signatures for additional insights into biology, regulation, pathways, drug responses, and sample populations. Research is "creative and systematic work undertaken to increase the stock of knowledge". It involves the collection, organization, and analysis of information to increase understanding of a topic or issue. A research project may be an expansion on past work in the field. To test the validity of instruments, procedures, or experiments, research may replicate elements of prior projects or the project as a whole.